Can
medication keep you sober? Probably not, but medication may help you
stay sober, especially when medications approved for the treatment of
alcoholism are combined with therapy.
While researchers have yet to find a real
medication-based cure for alcoholism (and research continues in
earnest), the U.S. Food and Drug Administration (FDA) has approved four
medications for use in treating the disorder. These medications are all
used to help people avoid relapse or decrease drinking.
The four medications approved by the FDA to treat alcoholism are:
- Acamprosate
- Oral naltrexone
- Injectable naltrexone
- Disulfiram
Why Use Medication?
Research shows that adding an approved medication for
alcoholism to counseling or other forms of addiction treatment improves
treatment outcomes. Alcoholism medications have been found to:
- Reduce enduring symptoms of withdrawal that can prompt relapse (acamprosate)
- Help minimize alcohol cravings
- Help recovering alcoholics who temporarily slip back into drinking to avoid complete relapse
- Prolong intervals between slips or relapses
- Increase the benefits of counseling or other alcohol treatments
Medication can help an alcoholic in early recovery stay
sober long enough to develop sober living and social skills that
provide a continuing base for further sobriety. These medications also
reduce the severity of cravings and withdrawal symptoms.
Acamprosate (Campral)
Acamprosate helps restore brain function damaged by alcoholism, and in doing so helps alcoholics maintain abstinence.
Alcohol causes intense but relatively brief withdrawal
symptoms, and much longer lasting but milder symptoms of withdrawal.
Although milder, these enduring withdrawal symptoms (such as difficulty
sleeping, irritability and anxiety) can lead to alcohol relapse.
Acamprosate helps motivated recovering alcoholics
maintain abstinence by reducing the severity of these longer lasting
withdrawal symptoms. Acamprosate is thought to reduce glutamate
activity, but its exact means of action remains poorly understood.
How Well Does Acamprosate Work?
Some studies show that acamprosate can double durations
of abstinence. Other studies have shown less impressive outcomes.
Acamprosate seems to work best for people who are motivated to stay
abstinent. It must be taken three times daily, so patient compliance is
very relevant.
Advantages of Acamprosate
- Acamprosate is not metabolized in the liver, and so can be used by patients with liver damage or cirrhosis.
- It can be used by patients taking methadone or
Suboxone, and by those who require opiates for pain control
(unlike naltrexone).
- It causes no withdrawal symptoms and can be
stopped suddenly if needed. It can also be taken safely with
benzodiazepines.
- It cannot be abused and it is not dangerous, even at overdose quantities.
- Side effects are generally minimal, and those that occur are well tolerated.
Acamprosate becomes fully effective between five and eight days after treatment initiation.
Oral Naltrexone (ReVia)
Patients taking oral naltrexone experience reduced
cravings for alcohol and, while taking the medication, drinking alcohol
won’t produce as much pleasure. Since drinking doesn’t make people on
naltrexone feel as good, people that slip while taking the medication
tend to drink lesser amounts.
Oral naltrexone works by blocking receptor neurons in the
brain’s natural opioid system. With these receptors blocked, consuming
alcohol is not as pleasurable. Additionally, neurons in the mesolimbic
system (the opioid system) are thought to be responsible, at least in
part, for alcohol cravings. Blocking these receptors with naltrexone
reduces craving intensity.
How Well Does Oral Naltrexone Work?
Oral naltrexone is effective at helping people maintain
abstinence or drink less. Studies of oral naltrexone have shown that,
compared to people taking a placebo, people taking the medication:
- Have lower rates of relapse
- If they do drink, drink less often and drink less in a sitting
Advantages of Oral Naltrexone
- It works well, particularly for people who
experience heavy alcohol cravings and who are motivated to
maintain abstinence.
- It is well tolerated, causing few side effects (the most common side effect is nausea).
- It has no abuse potential and causes no withdrawal symptoms.
Disadvantages of Oral Naltrexone
- It cannot be used by some people with liver problems.
- It cannot be used by anyone using methadone, Suboxone or requiring opiate pain medications.
- It may increase a person’s vulnerability to opiate overdose by decreasing opiate tolerance.
Most people begin oral naltrexone therapy within three to
seven days after achieving alcohol abstinence. Naltrexone is
FDA-approved for up to three consecutive months of treatment.
Injectable Naltrexone (Vivitrol)
Injectable naltrexone works in the same way as oral
naltrexone to reduce alcohol cravings and decrease the pleasures of
alcohol consumption. While oral naltrexone needs to be taken daily,
intramuscularly injected naltrexone works for a continuous month. With a
monthly injectable dose, everyday compliance is not an issue.
Studies that have examined the efficacy of naltrexone as
a treatment for alcoholism have consistently encountered patient
non-compliance as a barrier to successful treatment.
The advantages and disadvantages of injectable naltrexone
treatment closely mimic those of oral naltrexone treatment. The main
benefit of injectable naltrexone is increased patient compliance. Some
points of concern include:
- The possibility of an injection site reaction.
- The duration of effectiveness means that any adverse reactions experienced will be experienced for 30 days.
Disulfiram (Antabuse)
Patients talking disulfiram cannot consume alcohol
without becoming very ill. Patients taking this medication know this,
and so avoid drinking alcohol while taking the medication. This helps
people in recovery prolong abstinence and avoid relapse.
How Does Disulfiram Work?
Normally, alcohol is metabolized by the body into
acetaldehyde and then into acetic acid. Disulfiram disrupts the final
stage of this process (the metabolization of acetaldehyde into acetic
acid), causing a much higher level of acetaldehyde in the body after
any alcohol consumption.
High levels of acetaldehyde in the bloodstream lead to very uncomfortable reactions, such as the following:
- Hyperventilation
- Thirst
- Nausea and vomiting
- Chest pains
- Dizziness
- Confusion
- Muscle weakness
At higher doses, the combination of disulfiram and alcohol can lead to serious reactions that can include symptoms such as:
- Seizures
- Heart failure
- Respiratory depression
- Death
Disulfiram is no longer given in doses high enough to
likely cause a very severe or dangerous reaction. In the past,
disulfiram was given in high dosages to patients in combination with
alcohol, but that is no longer accepted medical practice.
Does Disulfiram Work?
Studies have shown that disulfiram helps to reduce
drinking days amongst the actively drinking, but does not seem to work
better than placebo in supporting abstinence. Patients who are
supervised while taking their medication (to ensure compliance) seem to
do better than those who are left unsupervised.
Disulfiram is not an appropriate medication for people with any of the following:
- Mental illness
- Poor impulse control
- Cognitive impairments
No one should take disulfiram without a full understanding of the effects and potential consequences of the medication.
Medications Can Help Support Recovery
Medications can play a very supportive role as one of
several pillars in a foundation of recovery. No medication yet available
for the treatment of alcoholism works very well when offered as a
standalone therapy — all must be combined with other therapies.
If you are interested in quitting drinking or reducing
your consumption of alcohol, talk to your doctor about your suitability
for any of the above medications. To find a doctor versed in
alcoholism recovery, contact the National Resource Center at (866)
762-3712. The center is a free service providing treatment specialists
24 hours a day to answer your questions and put you in contact with
appropriate healthcare professionals in your area.